AnSearch A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Iowa State University

Iowa State University
Picture of Christopher K.Tuggle
Christopher K. Tuggle
Professor
Iowa State University
2255 Kildee Hall
Ames, IA 50011-3150
Phone: 515-294-4252
Fax:     515-294-2401
Email: cktuggle@iastate.edu

Education
Doctor of Philosophy, University of Minnesota: 1986
Bachelor of Arts, St. Cloud State University: 1981

Awards
2001: Outstanding Young Scientist Award for Research (Midwest Sections of ASAS and ADSA)

Instruction
Dr. Tuggle teaches Animal Molecular Biology (AnS 451/551) and Current Topics in Genome Analysis (AnS 556).

Research
Information on Projects

Professional Affiliations
Interdepartmental Genetics (IG)
Molecular, Cellular and Developmental Biology (MCDB)
Bioinformatics and Computational Biology (BCB)
Visiting Scientist, Laboratoire de Genetique Cellulaire, INRA, Toulouse, France
NIH postdoctoral appointment, University of Southern California, LA, CA
Lecturer, International Congress on Genetic Engineering, Szeged, Hungary
NIH predoctoral fellow, University of Minnesota, Saint Paul, MN
American Society of Biochemistry and Molecular Biology
International Society of Animal Genetics

Selected Publications

Uthe, J.J., Royaee, A., Lunney, J.K., Stabel, T.J., Zhao, S.-H., Tuggle, C.K. , Bearson, S.M.D. 2007. The host-specific porcine response to Salmonella enterica serovars Choleraesuis and Typhimurium. (accepted, Molecular Immunology).

C.K. Tuggle, Y.F. Wang and O. Couture. 2007. INVITED REVIEW: Advances in Swine Transcriptomics. (accepted, International Journal of Biological Sciences).

Tuggle, C.K., Dekkers. J., J. Reecy. 2006. Integration of Structural and Functional Genomics. Animal Genetics 37 (Supp. 1): 1-6.

Zhao. S.H., D. Kuhar, J. K. Lunney, H. Dawson, C. Guidry, J.J. Uthe, S. M. D. Bearson, J. Recknor, D. Nettleton, C.K. Tuggle. 2006. Gene expression profiling in Salmonella Choleraesuis infected porcine lung using a long oligonucleotide microarray. Mammalian Genome 17:777-89.

Uthe, J.J., Stabel, T.J., Bearson, S.M.D., S.-H. Zhao, S.-H., Tuggle, C.K.. 2006. Analysis of Porcine Differential Gene Expression Following Challenge with Salmonella enterica Serotype Choleraesuis using Suppression Subtractive Hybridization. Vet. Micro. 114:60-71.

Zhao, S.-H. J. Recknor, J.K. Lunney, D. Nettleton, D. Kuhar, S. Orley, H. Dawson, C.K. Tuggle. 2005. Validating a first-generation porcine oligonucleotide microarray for transcriptional profiling in the pig. Genomics 86:618-625.

Abbott, M.A., and Tuggle, C.K.. 2005. Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons. Brain Res. Dev. Brain Res. 159:87-97.

Demeure, O., Pomp, D., Rothschild, M.F., Milan, D., Tuggle, C.K.. 2005. Large-scale EST mapping refines the comparative maps for SSC1 and SSC7 with the human genome. Animal Genetics 36:381-389.

Kim, J.W., S.-H. Zhao, J.J. Uthe, S.M.D. Bearson, C.K. Tuggle. 2005. Physical mapping of eight pig genes whose expression level is acutely affected by Salmonella challenge. Animal Genetics, 36: 359-362.

Caetano, A.R., Edeal, J.B., Burns, K., Johnson, R.K., Tuggle, C.K.. Pomp D. 2005. Physical Mapping of Genes in the Porcine Ovarian Transcriptome. Animal Genetics 36:322-330.

Joksimovic, M., Jeannotte, L., Tuggle, C.K.. 2005. Dynamic expression of murine HOXA5 protein in the central nervous system. Mechanisms of Development-Gene Expression Patterns 5: 792-800.

Tabariès, S., Lapointe, J., Besch, T., Carter, M., Woollard, J., Tuggle, C.K., and Jeannotte, L. 2005. Cdx Protein Interaction to Hoxa5 Regulatory Sequences Contributes to Hoxa5 Regional Expression along the Axial Skeleton. 2005. Molecular and Cellular Biology 25:1389-1401.

Lee, S.-H., Zhao, S.-H., Recknor, J., Nettleton, D., Orley, S., Kang S.-K., Lee B.-C., Hwang W.-S., Tuggle C.K. 2005. Transcriptional profiling using a novel cDNA array identifies differential gene expression during porcine embryo elongation. Mol. Reprod. Dev. 71:129-139.

Krieger, K.E., M.A. Abbott, M. Joksimovic, P.A. Lueth, I.M. Sonea, L. Jeannotte, and C.K. Tuggle. 2004. Transgenic mice ectopically expressing HOXA5 in the dorsal spinal cord (SC) show structural defects of the cervical SC along with sensory and motor defects of the forelimb. Brain Res. Develop. Brain Res. 150:125-139.

Moller, M., F. Berg, J. Riquet, D. Pomp, A. Archibald, S. Anderson, K. Feve, Y. Zhang, M.F. Rothschild, D. Milan, L. Andersson and C.K. Tuggle. 2004. High-resolution comparative mapping across pig chromosome 4 (SSC4), emphasizing the FAT1 region. Mammalian Genome 15: 717-31.

Zhao, S.-H., D. G. Simmons, J.C. Cross, T.E. Scheetz, T.L. Casavant, M. B. Soares, and C.K. Tuggle. 2004. PLET1, a highly expressed and processed novel gene in pig and mouse placenta is transcribed but poorly spliced in human. Genomics 84;114-125.

C.K. Tuggle, J.A. Green, C. Fitzsimmons, R. Woods, R.S. Prather, S. Malchenko, M.B. Soares, T. Kucaba, K. Crouch, C. Smith, D. Tack, N. Robinson, B. O’Leary, T. Scheetz, T. Casavant, D. Pomp. J.B. Edeal, Y. Zhang, M.F. Rothschild, K. Garwood, and W. Beavis. 2003. EST-based gene discovery in pig: virtual expression patterns and comparative mapping to human. Mamm. Gen. 14:565-579.

Sun, H.S., L. L. Anderson, T.-P. Yu, K.S. Kim, J. Klindt, and C.K. Tuggle. 2002. Neonatal Meishan pigs show POU1F1 genotype effects on plasma GH and PRL concentration. Anim. Reprod. Sci. 69:223-237.

Yu, T.-P., Sun, H. S., Wahls, S., I. Sanchez-Serrano, M. F. Rothschild, and C.K. Tuggle. 2001. Cloning of the full length pig PIT1 (POU1F1) cDNA and a novel alternative PIT1 transcript, and functional studies of their encoded proteins. Anim. Biotech. 12(1):1-19.

Nowling, T., W. Zhou, K.E. Krieger, C. Larochelle, M. C. Nguyen-Huu, L. Jeannotte, and C.K. Tuggle. 1999. Hoxa5 gene regulation: a gradient of binding to a brachial spinal cord element. Developmental Biology 208:134-146.

Supplemental Data to Publications
Pig Desmin cDNA Sequence and Comparisons
Muscle EST Data
PIT1 Sequence Analysis Data
Pig Muscle Macroarray Results (Excel)

Complete List of Tuggle Publications (PDF)

Class Bookmarks

Results from USDA-NRI Supported Project on Functional Genomics

  • EST-Based Gene Discovery in Pig (pdf)
  • Transcriptional Profiling in Pig Muscle (pdf)
  • Qiagen Pig Array Oligo Set (pdf)

  • Other Links
    Tuggle Lab Group
    USDA Project Identifying Pig Genes at ISU