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Iowa State University

Iowa State University
Picture of Christopher K.Tuggle
Christopher K. Tuggle
Iowa State University
2255 Kildee Hall
Ames, IA 50011-3150
Phone: 515-294-4252
Fax:     515-294-2401

Doctor of Philosophy, University of Minnesota: 1986
Bachelor of Arts, St. Cloud State University: 1981

2011: Outstanding Achievement in Research Award (Iowa State University College of Agriculture and Life Sciences)
2010-2011: National Fulbright Scholar Award (William J. Fulbright Commission)
2001: Outstanding Young Scientist Award for Research (Midwest Sections of ASAS and ADSA)
1996: Early Achievement in Research Award (Iowa State University Foundation)

Dr. Tuggle teaches Animal Molecular Biology (AnS 451/551) and Current Topics in Genome Analysis (AnS 556).

Information on Projects

Professional Affiliations and Committees
Interdepartmental Genetics (IG)
Molecular, Cellular and Developmental Biology (MCDB)
Bioinformatics and Computational Biology (BCB)
Visiting Professor, Huazhong Agricultural University, P.R. China
International Society of Animal Genetics

Selected Publications
Uthe J.J., Qu L., Couture, O., Bearson S.M.D., O’Connor A.M., McKean J.D., Rodriguez Torres Y., Dekkers J.C., Nettleton D., and C.K. Tuggle. 2011. Use of bioinformatic SNP predictions and gene expression profiling data to find and analyze SNPs associated with Salmonella colonization in swine. J. Animal Breeding and Genetics (in press).

Uthe J.J., Bearson S.M.D., Dekkers J.C., Qu L., Nettleton D., Rodriguez Torres Y., O’Connor A.M., McKean J.D., and C.K. Tuggle. 2011. Integrating Comparative Expression Profiling Data with Association of SNPs to Salmonella Shedding for Improved Food Safety and Porcine Disease Resistance. Animal Genetics (in press).

Tuggle, C.K., F. Towfic, and V. Honavar. 2011. Introduction to systems biology for animal scientists. In: Systems Biology and Livestock Science. M. te Pas, A. Bannink and H. Woelders (eds). John Wiley & Sons, Malden, MA pp 1-30.

Engrav, L. H., Tuggle, C.K., Kerr, K.F., Zhu, K.Q., Numhom, S., Couture, O.P., Beyer, R.P., Hocking, A.M., Carrougher, G.J., Ramos, M.L.C., Klein, M.B., Gibran, N.S. Functional Genomics Unique to Week 20 Post Wounding in the Deep Cone/Fat Dome of the Duroc/Yorkshire Porcine Model of Fibroproliferative Scarring. 2011. PLOS-One 6:e19024.

Ciraci, C., C.K. Tuggle, M. Wannemuehler, D. Nettleton, S.J. Lamont. 2010. Unique Genome-wide Transcriptome Profiles of Chicken Macrophages upon exposure to Salmonella-derived Endotoxin. BMC Genomics 11:545.

Tuggle, C.K., Bearson, S.M.D., Uthe, J.J., Huang, T.H., Couture, O.P., Y. F. Wang, Y.F., Kuhar, D., Lunney, J.K. and V. Honavar. 2010. Methods for transcriptomic analyses of the porcine host immune response: Application to Salmonella infection. Veterinary Immunology and Immunopathology 138:280–291.

Coulombe, Y., M. Lemieux, J. Moreau, J. Aubin, M. Joksimovic, Félix-Antoine Bérubé-Simard, S. Tabariès, O. Boucherat, F. Guillou, C. Larochelle, C.K. Tuggle and L. Jeannotte. 2010. Multiple Promoters and Alternative Splicing: Hoxa5 Transcriptional Complexity in the Mouse Embryo. PLOS-One 5:e10600.

Barb, C.R., Hausman, G.J., Rekaya, R. Lents, C.A., Lkhagvadorj, S., Qu, L., Cai, W., Couture, O.P., Anderson, L.L., Dekkers, J.C.M., Tuggle, C.K. 2010. Gene expression in hypothalamus, liver and adipose tissues and feed intake response to melanocortin-4 receptor (MC4R) agonist in pigs expressing MC4R mutations. Physiological Genomics 41: 254-268.

Towfic, F., VanderPlas, S., Oliver, C.A., Couture, O., Tuggle, C.K., Greenlee, M.H.W., and V. Honavar. 2010. Detection of Gene Orthology Based On Biomolecular Networks. BMC Bioinformatics 11:S7.

Lkhagvadorj, S., L. Qu, W. Cai, O. P. Couture, C. R. Barb, G. J. Hausman, D. Nettleton, L.L. Anderson, J.C.M. Dekkers, C.K. Tuggle. 2010. Gene expression profiling of the short-term adaptive response to acute caloric restriction in liver and adipose tissues of pigs differing in feed efficiency. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 298:494-507.

Couture, O., K. Callenberg, N. Koul, S. Pandit, R. Younes, Z. Hu, J. Dekkers, J. Reecy, V. Honavar, C.K. Tuggle. 2009. ANEXdb: an integrated animal Annotation and microarray EXpression database. Mammalian Genome 20:768-77.

Lkhagvadorj, S., Qu., L., Cai, W., Couture, O., Barb, C.R., Hausman, G., Nettleton, D., Anderson, L.L., Dekkers, J.C.M., C.K. Tuggle. 2009. Microarray gene expression profiles of fasting induced changes in liver and adipose tissues of pigs expressing the melanocortin-4 receptor D298N variant. Physiological Genomics 38:98-111.

Ross, J.A., M. D. Ashworth, D.R. Stein, O. Couture, C.K. Tuggle, and R. Geisert. 2009. Identification of Differential Gene Expression during Porcine Conceptus Rapid Trophoblastic Elongation and Attachment to the Uterine Luminal Epithelium. Physiological Genomics 36: 140-148.

Tuggle, C.K. and J. Dekkers. 2009. Genotyping: How useful is it to Producers? Pig Progress 25: 2-4.

Uthe, J.J., Y. Wang, L. Qu, D. Nettleton, C.K. Tuggle and S.M.D. Bearson. 2009. Correlating blood immune parameters and a CCT7 genetic variant with the shedding of Salmonella enterica serovar Typhimurium in swine. Veterinary Microbiology 135:384-388.

Wang Y.F., Couture O.P., Qu L., Uthe J.J., Bearson S.M.D., Kuhar D., Lunney J., Nettleton D., Dekkers J.C.M., and C.K. Tuggle. 2008. Analysis of Porcine Transcriptional Response to Salmonella Enterica Serovar Choleraesuis suggests novel targets of NF?B are activated in the Mesenteric Lymph Node. BMC Genomics 9:437.

Tuggle, C.K., Y. F. Wang, O. P. Couture, L. Qu, J. J. Uthe, D. Kuhar, J. K. Lunney, D. Nettleton, J. C. Dekkers, and S. M. D. Bearson. 2008. Computational integration of structural and functional genomics data across species to develop information on the porcine inflammatory gene regulatory pathway. Dev. Biol (Basel) 132:105-13.

Zhu, K. Q., Carrougher, G.J., Gibran, N.S., Couture, O.P., Tuggle, C.K., L.H. Engrav. 2008. Expression of Collagen Genes in the cones of skin in the Duroc/Yorkshire porcine model of Fibroproliferative scarring. Journal of Burn Care and Research 29:815-27 (PMC2853751).

Wang, Y.F., Qu, L., Uthe, J.J., Bearson, S.M.D., Kuhar, D., Lunney, J.K., Couture, O.P., Nettleton, D., Dekkers, J.C.M., and C.K. Tuggle. 2007. Global Transcriptional Response of Porcine Mesenteric Lymph Nodes to Salmonella enterica serovar Typhimurium. Genomics 90:72-84.

Uthe, J.J., Royaee, A., Lunney, J.K., Stabel, T.J., Zhao, S.-H., Tuggle, C.K., Bearson, S.M.D. 2007. Porcine differential gene expression in response to Salmonella enterica serovars Choleraesuis and Typhimurium. Molecular Immunology 44:2900-2914.

Tuggle, C.K., Y.F. Wang and O. Couture. 2007. INVITED REVIEW: Advances in Swine Transcriptomics. International Journal of Biological Sciences 3:132-152.

Tuggle, C.K., Dekkers. J., J. Reecy. 2006. Integration of Structural and Functional Genomics. Animal Genetics 37 (Supp. 1): 1-6.

Zhao. S.H., D. Kuhar, J. K. Lunney, H. Dawson, C. Guidry, J.J. Uthe, S. M. D. Bearson, J. Recknor, D. Nettleton, C.K. Tuggle. 2006. Gene expression profiling in Salmonella Choleraesuis infected porcine lung using a long oligonucleotide microarray. Mammalian Genome 17:777-89.

Uthe, J.J., Stabel, T.J., Bearson, S.M.D., S.-H. Zhao, S.-H., C.K. Tuggle. 2006. Analysis of Porcine Differential Gene Expression Following Challenge with Salmonella enterica Serotype Choleraesuis using Suppression Subtractive Hybridization. Vet. Micro. 114:60-71.

Kim, J.W., S.-H. Zhao, J.J. Uthe, S.M.D. Bearson, C.K. Tuggle. 2006. Assignment of the Scavenger receptor class B, member 2 (SCARB2) gene to Porcine Chromosome 8q11-q12 by somatic cell and radiation hybrid panel mapping. Cytogenet. Genome Res., 112:342H.

Complete List of Tuggle Publications (PDF)