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Christopher K. Tuggle Professor Iowa State University 2255 Kildee Hall Ames, IA 50011-3150 Phone: 515-294-4252 Fax: 515-294-2401 Email: cktuggle@iastate.edu |
Education Doctor of Philosophy, University of Minnesota: 1986 Bachelor of Arts, St. Cloud State University: 1981 | |
Awards 2001: Outstanding Young Scientist Award for Research (Midwest Sections of ASAS and ADSA) | |
Instruction Dr. Tuggle teaches Animal Molecular Biology (AnS 451/551) and Current Topics in Genome Analysis (AnS 556). | |
Research Information on Projects - Web format | |
Professional Affiliations Interdepartmental Genetics (IG) Molecular, Cellular and Developmental Biology (MCDB) Bioinformatics and Computational Biology (BCB) Visiting Professor, Huazhong Agricultural University, P.R. China International Society of Animal Genetics | |
Selected Publications Lkhagvadorj, S., Qu., L., Cai, W., Couture, O., Barb, C.R., Hausman, G., Nettleton, D., Anderson, L.L., Dekkers, J.C.M.,C.K. Tuggle. 2009. Microarray gene expression profiles of fasting induced changes in liver and adipose tissues of pigs expressing the melanocortin-4 receptor D298N variant. Physiological Genomics 38:98-111. Ross, J.A., M. D. Ashworth, D.R. Stein, O. Couture, C.K. Tuggle, and R. Geisert. 2009. Identification of Differential Gene Expression during Porcine Conceptus Rapid Trophoblastic Elongation and Attachment to the Uterine Luminal Epithelium. Physiological Genomics 36: 140-148. Uthe, J.J., Y. Wang, L. Qu, D. Nettleton, C.K. Tuggle and S.M.D. Bearson 2009. Correlating blood immune parameters and a CCT7 genetic variant with the shedding of Salmonella enterica serovar Typhimurium in swine. Veterinary Microbiology 135:384-388. Wang Y.F., Couture O.P., Qu L., Uthe J.J., Bearson S.M.D., Kuhar D., Lunney J., Nettleton D., Dekkers J.C.M., and C.K. Tuggle. 2008. Analysis of Porcine Transcriptional Response to Salmonella Enterica Serovar Choleraesuis suggests novel targets of NFB are activated in the Mesenteric Lymph Node. BMC Genomics 9:437. Tuggle, C.K.., Y. F. Wang, O. P. Couture, L. Qu, J. J. Uthe, D. Kuhar, J. K. Lunney, D. Nettleton, J. C. Dekkers, and S. M. D. Bearson. 2008. Computational integration of structural and functional genomics data across species to develop information on the porcine inflammatory gene regulatory pathway. Dev. Biol (Basel) 132:105-13. Zhu, K. Q., Carrougher, G.J., Gibran, N.S., Couture, O.P., Tuggle, C.K., L.H. Engrav. 2008. Expression of Collagen Genes in the cones of skin in the Duroc/Yorkshire porcine model of Fibroproliferative scarring. Journal of Burn Care and Research 29:815-27. Wang, Y.F., Qu, L., Uthe, J.J., Bearson, S.M.D., Kuhar, D., Lunney, J.K., Couture, O.P., Nettleton, D., Dekkers, J.C.M., and C.K. Tuggle. 2007. Global Transcriptional Response of Porcine Mesenteric Lymph Nodes to Salmonella enterica serovar Typhimurium. Genomics 90:72-84. Uthe, J.J., Royaee, A., Lunney, J.K., Stabel, T.J., Zhao, S.-H., Tuggle, C.K., Bearson, S.M.D. 2007. Porcine differential gene expression in response to Salmonella enterica serovars Choleraesuis and Typhimurium. Molecular Immunology 44:2900-2914. Tuggle, C.K., Y.F. Wang and O. Couture. 2007. INVITED REVIEW: Advances in Swine Transcriptomics. International Journal of Biological Sciences 3:132-152. Tuggle, C.K., Dekkers. J., J. Reecy. 2006. REVIEW: Integration of Structural and Functional Genomics. Animal Genetics 37 (Supp. 1): 1-6. Zhao. S.H., D. Kuhar, J. K. Lunney, H. Dawson, C. Guidry, J.J. Uthe, S. M. D. Bearson, J. Recknor, D. Nettleton, C.K. Tuggle. 2006. Gene expression profiling in Salmonella Choleraesuis infected porcine lung using a long oligonucleotide microarray. Mammalian Genome 17:777-89. Zhao, S.-H. J. Recknor, J.K. Lunney, D. Nettleton, D. Kuhar, S. Orley, H. Dawson, C.K. Tuggle. 2005. Validating a first-generation porcine oligonucleotide microarray for transcriptional profiling in the pig. Genomics 86:618-625. Abbott, M.A., and C.K. Tuggle. 2005. Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons. Brain Res. Dev. Brain Res. 159:87-97. Demeure, O., Pomp, D., Rothschild, M.F., Milan, D., C.K. Tuggle. 2005. Large-scale EST mapping refines the comparative maps for SSC1 and SSC7 with the human genome. Animal Genetics 36:381-389. Joksimovic, M., Jeannotte, L., C.K. Tuggle. 2005. Dynamic expression of murine HOXA5 protein in the central nervous system. Mechanisms of Development-Gene Expression Patterns 5: 792-800. Tabariès, S., Lapointe, J., Besch, T., Carter, M., Woollard, J., Tuggle, C.K., and Jeannotte, L. 2005. Cdx Protein Interaction to Hoxa5 Regulatory Sequences Contributes to Hoxa5 Regional Expression along the Axial Skeleton. 2005. Molecular and Cellular Biology 25:1389-1401. Lee, S.-H., Zhao, S.-H., Recknor, J., Nettleton, D., Orley, S., Kang S.-K., Lee B.-C., Hwang W.-S., Tuggle, C.K. 2005. Transcriptional profiling using a novel cDNA array identifies differential gene expression during porcine embryo elongation. Mol. Reprod. Dev. 71:129-139. Krieger, K.E., M.A. Abbott, M. Joksimovic, P.A. Lueth, I.M. Sonea, L. Jeannotte, and C.K. Tuggle. 2004. Transgenic mice ectopically expressing HOXA5 in the dorsal spinal cord (SC) show structural defects of the cervical SC along with sensory and motor defects of the forelimb. Brain Res. Develop. Brain Res. 150:125-139. Zhao, S.-H., D. G. Simmons, J.C. Cross, T.E. Scheetz, T.L. Casavant, M. B. Soares, and C.K. Tuggle. 2004. PLET1, a highly expressed and processed novel gene in pig and mouse placenta is transcribed but poorly spliced in human. Genomics 84;114-125. Tuggle, C.K., J.A. Green, C. Fitzsimmons, R. Woods, R.S. Prather, S. Malchenko, M.B. Soares, T. Kucaba, K. Crouch, C. Smith, D. Tack, N. Robinson, B. O’Leary, T. Scheetz, T. Casavant, D. Pomp. J.B. Edeal, Y. Zhang, M.F. Rothschild, K. Garwood, and W. Beavis. 2003. EST-based gene discovery in pig: virtual expression patterns and comparative mapping to human. Mammalian Genome 14:565-579. | |