AnSearch A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Iowa State University

Iowa State University
Picture of N. MatthewEllinwood
N. Matthew Ellinwood
Associate Professor
Iowa State University
2356D Kildee Hall
Ames, IA 50011-3150
Phone: 515-294-5136
For Advisor Appointments call 515-294-1427
Fax:     515-294-4471
Email: mellinwo@iastate.edu

Education
Colorado State University, Veterinary Medicine DVM, 1997
Colorado State University, Physiology PhD, 2000

Awards
Phi Zeta Veterinary Honor Society
Postdoctoral Travel Award, UCLA
Award for Excellence in Small Animal Clinical Nutrition

Research
Dr. Ellinwood's research interests include pathogenesis and therapies of genetic diseases in animals as models for human disease, pathogenesis of neuropathic lysosomal storage diseases, viral pathogenesis and interferon-mediated resistance to viral infection, and clinical applications and basic research in canine reproduction.

Professional Affiliations
American Association for the Advancement of Science
American Society for Gene Therapy
American Society of Human Genetics
American Veterinary Medical Association
International Society for Interferon and Cytokine Research
National MPS Society, Inc.
Society of the Study of Inborn Errors of Metabolism

Selected Publications
Vite C.H., Nestrasil I., Mlikotic A., Jens J.K., Snella E.M., Gross W., Shapiro E.G., Kovac V., Provenzale J., Chen S., Le S.Q., Kan S.-h., Banakar S., Wang R.Y., Haskins M.E., Ellinwood N.M., Dickson P.I. Brain magnetic resonance imaging findings in canine mucopolysaccharidosis type I and response to therapy. Comparative Medicine. 2013. 163-173.

Brim B., Haskell R., Awedikian R., Ellinwood N.M., Jin L., Magnusson K. Memory in aged mice is rescued in different learning phases with increased expression of the GluN2B subunit of the N-methyl-D-aspartate receptor in the frontal cortex versus the hippocampus. Behavioral Brain Research. 2013. 238. 211-226.

Mohammed E.E., Snella E.M., Rutz-Mendicino M.M., Echevarria F.D., Awedikian R., Whitley E.M., Ellinwood N.M.. Accelerated clinical disease and pathology in mucopolysaccharidosis type IIIB and GalNAc transferase double knockout mice. Mol Genet Metab. 2012. 107. 129-35.

Dickson P.I., Ellinwood N.M., Brown J.R., Witt R.G., Lea S.Q., Passage M.B., Vera M.U., Crawford B.E. Specific antibody titer alters the effectiveness of intrathecal enzyme replacement therapy in canine mucopolysaccharidosis I. Molecular Genetics and Metabolism. 2012. 106. 68-72.

Ponder K.P., O'Malley T.M., Wang P., O'Donnell P.A., Traas A.M., Knox V.W., Aguirre G.A., Ellinwood N.M., Metcalf J.A., Wang B., Parkinson-Lawrence E.J., Sleeper M.M., Brooks D.A., Hopwood J.J., Haskins M.E. Neonatal gene therapy with a gamma retroviral vector in mucopolysaccharidosis VI cats. Molecular Therapy. 2012. 20. 898-907.

Christensen B.W., Asa C.S., Wang C., Vansandt L., Bauman K., Callahan M., Jens J.K., Ellinwood N.M. Effect of semen collection method on sperm motility of gray wolves (Canis lupus) and domestic dogs (C. l. familiaris). Theriogenology. 2011. 76. 975-980.

Chen A., Vogler C., McEntee M., Hanson S., Ellinwood N.M., Jens J., Snella E., Passage M., Le S., Guerra C., Dickson P. Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase. APMIS. 2011. 119 513-521.

Vite C.H., Wang P., Patel R.T., Walton R.M., Walkley S.U., Sellers R.S., Ellinwood N.M., Cheng A.S., White J.T., O'Neill C.A., Haskins M. Biodistribution and pharmacodynamics of recombinant human alpha-l-iduronidase (rhIDU) in mucopolysaccharidosis type I-affected cats following multiple intrathecal administrations. Mol Genet Metab. 2011. Jul. 103. 268-74.

Rutz-Mendicino M.M., Snella E.M., Jens J.K., Gandolfi B., Carlson S.A., Kuehn M.H., McLellan G.J.,Ellinwood N.M. The Identification and Removal of Potentially Confounding Phenotypes from a Siamese-Derived Feline Glaucoma Breeding Colony. Comparative Medicine. 2011. 61. 251-257.

Lyons J., Dickson P., Wall J., Passage M., Ellinwood N.M., Kakkis E., McEntee M.. Arterial Pathology in Canine Mucopolysaccharidosis-I and Response to Therapy. Laboratory Investigation. 2011. 91. 665-674.

Ellinwood N.M., Ausseil J., Desmaris N., Bigou S., Liu S., Jens J.K., Snella E.M., Mohammed E.E.A., Thomson C.B., Raoul S., Joussemet B., Roux F., Chérel Y., Lajat Y., Piraud M., Benchaouir R., Hermening S., Petry H., Froissart R., Tardieu M., Ciron C., Moullier P., Parkes J., Kline K.L., Maire I., Vanier M.-T., Heard J.-M., Colle M.-A. Safe, efficient and reproducible gene therapy of the brain in the dog models of Sanfilippo and Hurler syndromes. Molecular Therapy. 2011. 19. 251-259.

Dierenfeld A.D., McEntee M.F., Passage M., Le S., Jens J.K., Snella E.M., Kline K.L., Parkes J.D., Ware W.A., Moran L.E., Wengert J.A., Whitley R.D., Betts D., Boal A., Riedesel E.A., Gross W., Ellinwood N.M., Dickson P.I. Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I. Science Translational Medicine. 2010. 2. 54-61.

Dickson P.I., Hanson S., McEntee M.F., Vite C., Vogler C., Mlikotic A., Chen A.H., Ponder K.P., Haskins M., Tippin B.L., Le S.Q., Passage M., Guerra C., Dierenfeld A., Jen J.K., Snella E., Kana S.-h., Ellinwood N.M. Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I. Molecular Genetics and Metabolism. 2010. 101. 115-122.

Gross W., Garcia-Tapia D., Riedesel E.A., Ellinwood N.M., Jens J.K. Normal Canine Brain Maturation at Magnetic Resonance Imaging. Veterinary Radiology and Ultrasound. Veterinary Radiology & Ultrasound. 2010. 51. 361–373.

Ellinwood N.M., Clay C.M. Large animal models of genetic disease: pertinent IACUC issues. ILAR Journal. 2009. 2: 225-228.

Carlstrom L.P., Jens J.K., Dobyns M.E., Passage M., Dickson P.I., Ellinwood N.M. Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony. Comp Med. 2009. 59. 378-382.

Lhériteau E., Libeau L., Stieger K., Deschamps J.Y., Mendes-Madeira A., Provost N., Lemoine F., Mellersh C., Ellinwood N.M., Cherel Y., Moullier P., Rolling F. The RPGRIP1-deficient dog, a promising canine model for gene therapy. Mol Vis. 2009. 15. 349-361.

Ellinwood N.M., Colle M.-A., Weil M.A., Casal M.L., Vite C.H., Wiemelt S., Hasson C.W., O'Malley T.M., He X.X., Prociuk U., Verot L., Melniczek J.R., Lannon A., Aguirre G.D., Knox V.W., Evans S.M., Vanier M.T., Schuchman E.H., Walkley S.U., Haskins M.E. Bone marrow transplantation for feline mucopolysaccharidosis. Mol Genet Metab. 2007. 91: 239-250.

Rothschild M.F., Van Cleave P.S., Glenn K.L., Carlstrom L.P., Ellinwood N.M. Association of MITF with white spotting in Beagle crosses and Newfoundland dogs. Anim Genet. 2006. 37: 606-607.

Ponder K.P., Wang B., Wang P., Ma X., Herati R., Wang B., Cullen K., O'Donnell P., Ellinwood N.M., Traas A., Primeau T.M., Haskins M.E. Mucopolysaccharidosis I cats mount a cytotoxic T lymphocyte response after neonatal gene therapy that can be blocked with CTLA4-Ig. Mol Ther. 2006. 14: 5-13.

Wang B., O'Malley T.M., Xu L., Vite C., Wang P., O'Donnell P.A., Ellinwood N.M., Haskins M.E., Ponder K.P. Expression in blood cells may contribute to biochemical and pathological improvements after neonatal intravenous gene therapy for mucopolysaccharidosis VII in dogs. Mol Genet Metab. 2006. 87: 8-21.

Sleeper M.M., Fornasari B., Ellinwood N.M., Weil M.A., Melniczek J., O'Malley T.M., Sammarco C.D., Xu L., Ponder K.P., Haskins M.E. 2004. Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII. Circulation 110: 815-820.

Ellinwood N.M., Vite C.H., Haskins M.E. 2004. Gene therapy for lysosomal storage diseases: The lessons and promise of animal models. J Gene Med 6: 481-506.

Ellinwood N.M., Wang P., Skeen T., Sharp N.J., Cesta M., Decker S., Edwards N.J., Bublot I., Thompson J.N., Bush W., Hardam E., Haskins M.E., Giger U. 2003. A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-alpha-D-glucosaminidase deficiency in Schipperke dogs. J Inherit Metab Dis 26: 489-504.

Schmutz S.M., Berryere T.G., Ellinwood N.M., Kerns J.A., Barsh G.S. 2003. MC1R studies in dogs with melanistic mask or brindle patterns. J Hered 94: 69-73.

Haskins M., Casal M., Ellinwood N.M., Melniczek J., Mazrier H., Giger U. 2002. Animal models for mucopolysaccharidoses and their clinical relevance. Acta Paediatr Suppl 91: 88-97.

Xu L., Mango R.L., Sands M.S., Haskins M.E., Ellinwood N.M., Ponder KP. 2002. Evaluation of pathological manifestations of disease in mucopolysaccharidosis VII mice after neonatal hepatic gene therapy. Mol Ther 6: 745-758.

Ponder K.P., Melniczek J.R., Xu L., Weil M.A., O'Malley T.M., O'Donnell P.A., Knox V.W., Aguirre G.D., Mazrier H., Ellinwood N.M., Sleeper M., Maguire A.M., Volk S.W., Mango R.L., Zweigle J., Wolfe J.H., Haskins M.E. 2002. Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proc Natl Acad Sci USA 99: 13102-13107.

Hartnett B.J., Yao D., Suter S.E., Ellinwood N.M., Henthorn P.S., Moore P.E., McSweeney P.A., Nash R.A., Brown J.D., Weinberg K.I., Felsburg P.J. 2002. Transplantation of X-linked severe combined immunodeficient dogs with CD34+bone marrow cells. Biol Blood Marrow Transplant 8: 188-197.

Xu L., Haskins M.E., Melniczek J.R., Gao C., Weil M.A., O'Malley T.M., O'Donnell P.A., Mazrier H., Ellinwood N.M., Zweigle J., Wolfe J.H., Ponder K.P. 2002. Transduction of hepatocytes after neonatal delivery of a Moloney murineleukemia virus based retroviral vector results in long-term expression of beta-glucuronidase in mucopolysaccharidosis VII dogs. Mol Ther 5: 141-153.

Ellinwood N.M., Berryere T.G., Fournier B.P., Bowen R.A., Buchanan F.C., Schmutz S.M. 1999. MX1 maps to cattle chromosome 1. Anim Genet 30: 164-165.

Ellinwood N.M., McCue J.M., Gordy P.W., Bowen R.A. 1998. Cloning and characterization of cDNAs for a bovine (Bos taurus) Mx protein. J Interferon Cytokine Res 18: 745-755.

Veeramachaneni D.N., Smith M.O., Ellinwood N.M. 1998. Deficiency of fucosidase results in acrosomal dysgenesis and impaired sperm maturation.J Androl 19: 444-449.