AnSearch A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Iowa State University

Iowa State University
Picture of N. MatthewEllinwood
N. Matthew Ellinwood
Assistant Professor
Iowa State University
2356D Kildee Hall
Ames, IA 50011-3150
Phone: 515-294-5136
Fax:     515-294-4471
Email: mellinwo@iastate.edu

Education
Colorado State University, Veterinary Medicine DVM, 1997
Colorado State University, Physiology PhD, 2000

Awards
Phi Zeta Veterinary Honor Society
Postdoctoral Travel Award, UCLA
Award for Excellence in Small Animal Clinical Nutrition

Research
Dr. Ellinwood's research interests include pathogenesis and therapies of genetic diseases in animals as models for human disease, pathogenesis of neuropathic lysosomal storage diseases, viral pathogenesis and interferon-mediated resistance to viral infection, and clinical applications and basic research in canine reproduction.

Professional Affiliations
American Association for the Advancement of Science
American Society for Gene Therapy
American Society of Human Genetics
American Veterinary Medical Association
International Society for Interferon and Cytokine Research
National MPS Society, Inc.
Society of the Study of Inborn Errors of Metabolism

Selected Publications

Sleeper M.M., Fornasari B., Ellinwood N.M., Weil M.A., Melniczek J., O'Malley T.M., Sammarco C.D., Xu L., Ponder K.P., Haskins M.E. 2004. Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII. Circulation 110: 815-820.

Ellinwood N.M., Vite C.H., Haskins M.E. 2004. Gene therapy for lysosomal storage diseases: The lessons and promise of animal models. J Gene Med 6: 481-506.

Ellinwood N.M., Wang P., Skeen T., Sharp N.J., Cesta M., Decker S., Edwards N.J., Bublot I., Thompson J.N., Bush W., Hardam E., Haskins M.E., Giger U. 2003. A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-alpha-D-glucosaminidase deficiency in Schipperke dogs. J Inherit Metab Dis 26: 489-504.

Schmutz S.M., Berryere T.G., Ellinwood N.M., Kerns J.A., Barsh G.S. 2003. MC1R studies in dogs with melanistic mask or brindle patterns. J Hered 94: 69-73.

Haskins M., Casal M., Ellinwood N.M., Melniczek J., Mazrier H., Giger U. 2002. Animal models for mucopolysaccharidoses and their clinical relevance. Acta Paediatr Suppl 91: 88-97.

Xu L., Mango R.L., Sands M.S., Haskins M.E., Ellinwood N.M., Ponder KP. 2002. Evaluation of pathological manifestations of disease in mucopolysaccharidosis VII mice after neonatal hepatic gene therapy. Mol Ther 6: 745-758.

Ponder K.P., Melniczek J.R., Xu L., Weil M.A., O'Malley T.M., O'Donnell P.A., Knox V.W., Aguirre G.D., Mazrier H., Ellinwood N.M., Sleeper M., Maguire A.M., Volk S.W., Mango R.L., Zweigle J., Wolfe J.H., Haskins M.E. 2002. Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proc Natl Acad Sci USA 99: 13102-13107.

Hartnett B.J., Yao D., Suter S.E., Ellinwood N.M., Henthorn P.S., Moore P.E., McSweeney P.A., Nash R.A., Brown J.D., Weinberg K.I., Felsburg P.J. 2002. Transplantation of X-linked severe combined immunodeficient dogs with CD34+bone marrow cells. Biol Blood Marrow Transplant 8: 188-197.

Xu L., Haskins M.E., Melniczek J.R., Gao C., Weil M.A., O'Malley T.M., O'Donnell P.A., Mazrier H., Ellinwood N.M., Zweigle J., Wolfe J.H., Ponder K.P. 2002. Transduction of hepatocytes after neonatal delivery of a Moloney murineleukemia virus based retroviral vector results in long-term expression of beta-glucuronidase in mucopolysaccharidosis VII dogs. Mol Ther 5: 141-153.

Ellinwood N.M., Berryere T.G., Fournier B.P., Bowen R.A., Buchanan F.C., Schmutz S.M. 1999. MX1 maps to cattle chromosome 1. Anim Genet 30: 164-165.

Ellinwood N.M., McCue J.M., Gordy P.W., Bowen R.A. 1998. Cloning and characterization of cDNAs for a bovine (Bos taurus) Mx protein. J Interferon Cytokine Res 18: 745-755.

Veeramachaneni D.N., Smith M.O., Ellinwood N.M. 1998. Deficiency of fucosidase results in acrosomal dysgenesis and impaired sperm maturation.J Androl 19: 444-449.