![]() |
Michael Spurlock Associate Professor Iowa State University 1109 HNSB Ames, IA 50011-1123 Phone: 515-294-8730 Fax: 515-294-5390 Email: mspurloc@iastate.edu |
Education Doctor of Philosophy, University of Missouri | |
Research The mechanisms underlying inflammation in adipose tissue and insulin resistance in relation to obesity. | |
Selected Publications Ajuwon, K.M., and Spurlock, M.E., 2005. Adiponectin attenuates lipopolysaccharide-induced NFkB activation and IL-6 expression, and up regulates PPAR expression in adipocytes. Am. J. Physiol. 288(5):R1220-5. Wulster-Radcliffe, M.C. and Spurlock, M.E., 2005. Adiponectin suppresses proliferation and proinflammatory cytokine production in THP-1 monocytes, and induces caspase 3/7 activity. Adipocytes 1:35-42. Ajuwon, K.M. and Spurlock, M.E., 2005. Palmitate activates the nuclear factor kappa-B transcription factor and induces IL-6 and TNF production in 3T3-L1 adipocytes. J. Nutr. 135:1841-1846. Ajuwon KM, Spurlock, M.E.. Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. J Nutr. 2005 Aug;135(8):1841-6. PMID: 16046706 [PubMed - in process] Ajuwon KM, Spurlock, M.E.. Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1220-5. Epub 2004 Dec 16. PMID: 15604306 [PubMed - indexed for MEDLINE] Jacobi SK, Ajuwon KM, Weber TE, Kuske JL, Dyer CJ, Spurlock, M.E.. Cloning and expression of porcine adiponectin, and its relationship to adiposity, lipogenesis and the acute phase response. J Endocrinol. 2004 Jul;182(1):133-44. PMID: 15225138 [PubMed - indexed for MEDLINE] Weber TE, Spurlock, M.E.. Leptin alters antibody isotype in the pig in vivo, but does not regulate cytokine expression or stimulate STAT3 signaling in peripheral blood monocytes in vitro. J Anim Sci. 2004 Jun;82(6):1630-40. PMID: 15216988 [PubMed - indexed for MEDLINE] Ajuwon KM, Spurlock, M.E.. Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes. Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R608-11. Epub 2004 May 20. PMID: 15155279 [PubMed - indexed for MEDLINE] Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock, M.E.. Adiponectin differentially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun. 2004 Apr 9;316(3):924-9. PMID: 15033490 [PubzMed - indexed for MEDLINE] Ajuwon KM, Jacobi SK, Kuske JL, Spurlock, M.E.. Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes. Am J Physiol Regul Integr Comp Physiol. 2004 Mar;286(3):R547-53. Epub 2003 Dec 4. PMID: 14656772 [PubMed - indexed for MEDLINE] Ajuwon KM, Kuske JL, Anderson DB, Hancock DL, Houseknecht KL, Adeola O, Spurlock, M.E.. Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue. J Nutr Biochem. 2003 Oct;14(10):576-83. PMID: 14559108 [PubMed - indexed for MEDLINE] Raman P, Donkin SS, Spurlock, M.E.. Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures. Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R206-16. Epub 2003 Sep 25. PMID: 14512272 [PubMed - indexed for MEDLINE] | |